Laurie's first Melbourne International Comedy Festival show was Dairy Belles which she performed with Corinne Grant. In 1998 she was granted the Brian McCarthy Memorial Moosehead Award to produce The Virgin Mary 2 - This Time It's Personal. Her success began to skyrocket when, in 2000, she debuted The Whore Whisperer: Confessions of a Madam at the Melbourne Fringe Festival - a show all about her experiences working in brothels. A sell-out in its first season, The Whore Whisperer went on to sell out seasons at the Adelaide Fringe, Melbourne International Comedy Festival, the Edinburgh Fringe and the Sydney Opera House.
In 2000, Laurie co-hosted Enough Rope on 3RRR with Josh Kinal. This was a weekly programme about comedy that included the comedy tracks, a look at the comedy industry and interviews with numerous guests including: Wil Anderson, Daniel Kitson, Simon Munnery, Rachel Berger. Regular segments featured Adam Richard and Toby Sullivan. The show was controversially cancelled at the end of 2002.
In 2004, Laurie hosted Stand Up!, a comedy show on ABC TV. She was also a regular on national variety show Rove Live.[6] Laurie has also appeared on The Glass House, Spicks and Specks, Good News Week, ADbc,[7] The Circle and The Project.
In 2005, Meshel joined Nova 106.9 in Brisbane as a founding breakfast presenter on Meshel, Ash, Kip and Luttsy - it became the highest rating breakfast show in Brisbane. Over the years Ash, Kip and Luttsy resigned with other presenters joining Laurie including Tim Blackwell and Marty Sheargold. Meshel, Tim and Marty remained in breakfast until August 2011 when the show was moved to Melbourne to broadcast live nationally on Drive on Nova FM. 
In October 2013, Nova 100 announced that she would join Tommy Little to host Meshel & Tommy replacing Hughesy & Kate.The show started in December 2013.
Since July 2013, Meshel has co-hosted This Week Live, alongside Dave Thornton, Tommy Little and Tom Gleeson.
In January 2014, Meshel was replaced by Kate Ritchie on drive joining Tim Blackwell and Marty Sheargold..

Meshel Laurie was born in Toowoomba, Queensland.